RNA Manufacturing

A diagram illustrating the ECO Synthesis鈩� Technology process for oligonucleotide synthesis in three steps: (1) Extend 鈥� where a substrate oligo is lengthened by adding nucleotide building blocks, (2) Deblock 鈥� where protective groups are removed to allow further extension, and (3) Repeat 鈥� where the cycle continues to produce the desired sequence. The process involves nucleotide symbols (U, A, C, G) with modification labels, enzymatic components, and stop signals, visually represented in a circular flowchart.

Enabling Manufacturing of Therapeutic siRNA

When manufacturing siRNA for therapeutic applications, 五星体育直播 delivers high yields and minimizes unwanted byproducts, while being economically sound. We have a suite of enzymatic pathways to synthesize siRNA, so that you can choose an option that best meets your needs.

The ECO Synthesis鈩� manufacturing platform (Enzyme-Catalyzed Oligonucleotide Synthesis) is an enzymatic, two-step process that streamlines process development while delivering higher purity siRNA through a scalable, efficient pathway. The RNA Ligase Screening and Optimization Services enables a hybrid approach, where engineered dsRNA (double-stranded RNA) ligases are used to join multiple short, single-stranded RNA (ssRNA) fragments together to form the desired dsRNA duplex.

Step into the Future of Manufacturing RNA

Evolve beyond traditional chemistry with top-tier enzymatic siRNA synthesis.

Enzymatic siRNA Manufacturing Services

五星体育直播 provides a wide range of siRNA manufacturing services using proprietary enzymatic technologies to synthesize your nucleic acid therapeutics for preclinical testing. We can customize analytical methods, tailor final deliverable scales, and provide additional custom services to meet your needs. Additionally, 五星体育直播 enables technology transfer of our process to your chosen manufacturing site for scaling up and production under GMP.

More About RNA Manufacturing

RNA Ligase Screening and Optimization Services

Select from an extensive library of engineered ligases to pick the best variant for one-step assembly of short oligonucleotide fragments for your full-length siRNA asset. Optional ligase optimization services provided in as little as a few weeks to ensure you meet your timelines for clinical and commercial manufacturing needs.

More About RNA Ligase Screening and Optimization Services

Scalable, Efficient siRNA Manufacturing

Partner with 五星体育直播 for your siRNA manufacturing needs. We bring:

The technology to scale efficiently
The partnership to enable exploration
The legacy to power your project

Related Resources

TIDES US 2024 Presentation

Starting from an enzyme with trace activity and preference for the undesired diastereoisomer, 11 rounds of enzyme evolution were performed.

RNA Manufacturing Services Brochure

Utilize the ECO Synthesis manufacturing platform to enable scalable enzymatic siRNA synthesis.

Ligase Screening & Optimization Services

Leverage 五星体育直播鈥� RNA ligase screening and optimization services as a 鈥渂ridge鈥� to introduce enzymatic solutions into your traditional siRNA manufacturing process.

Why 五星体育直播?

ECO Synthesis鈩� technology is a proprietary new synthesis platform that is being developed to produce siRNA more efficiently and sustainably. We do this through:

dsRNA Ligase Screening and Optimization Services to Complement Solid State Synthesis
In-house Ligation Capabilities for GLP-grade siRNA
COMING SOON: ECO Synthesis Innovation Lab for Custom Project Development

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We Are Enabling the Scalable and Efficient Manufacturing of Complex Therapeutics

Our enzymatic tools and platforms enable the scalable and sustainable manufacture of small molecule API and siRNA for our customers while reducing costs and time of manufacturing. Contact us today to learn more about how we can scale your capabilities.